Version 5.4
Homo sapiens Protein: PAG1
Summary
InnateDB Protein IDBP-26544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAG1
Protein Name phosphoprotein associated with glycosphingolipid microdomains 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000220597
InnateDB Gene IDBG-26542 (PAG1)
Protein Structure
UniProt Annotation
Function Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269PubMed:10790433}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:10790433, ECO:0000269PubMed:18070987}; Single-pass type III membrane protein {ECO:0000269PubMed:10790433, ECO:0000269PubMed:18070987}. Note=Present in lipid rafts.
Disease Associations
Tissue Specificity Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). {ECO:0000269PubMed:10790433, ECO:0000269PubMed:16160011}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0042169 SH2 domain binding
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0035556 intracellular signal transduction
GO:0050852 T cell receptor signaling pathway
GO:0050863 regulation of T cell activation
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWQ8
PhosphoSite PhosphoSite-Q9NWQ8
TrEMBL
UniProt Splice Variant
Entrez Gene 55824
UniGene Hs.673010
RefSeq NP_060910
HUGO HGNC:30043
OMIM 605767
CCDS CCDS6227
HPRD 16944
IMGT
EMBL AF240634 AK000680 AK289818 BC090931 BC112159 CH471068
GenPept AAF67343 AAH90931 AAI12160 BAA91321 BAF82507 EAW87086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca