InnateDB Protein
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IDBP-265559.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sept4
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Protein Name
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septin 4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103594
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InnateDB Gene
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IDBG-207394 (Sept4)
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Protein Structure
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Function |
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). {ECO:0000250, ECO:0000305}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12581152, ECO:0000269PubMed:17546647}. Cytoplasm, cytoskeleton {ECO:0000250}.Isoform 4: Mitochondrion. Note=In retinoic acid-treated P19 cells, isoform 4 is found first in the mitochondria and at later times, as neuronal differentiation proceeds, in the cytosol.
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Disease Associations |
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Tissue Specificity |
Expressed in the brain. Abundant in areas of high cell density, particularly in the stria terminalis. Isoform 4 is predominantly expressed in embryonic mouse brain and dorsal root ganglion neurons. {ECO:0000269PubMed:12581152}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1270156
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InterPro |
IPR000038
Cell division protein GTP binding
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00735
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P28661
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PhosphoSite |
PhosphoSite-P28661
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18952
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UniGene |
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RefSeq |
NP_001271323
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MGI ID |
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MGI Symbol |
Sept4
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OMIM |
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CCDS |
CCDS70276
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HPRD |
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IMGT |
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EMBL |
AB078010
AK133933
AK135143
AK137299
AL596086
BC055101
CH466556
CU406988
X61452
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GenPept |
AAH55101
BAC55241
BAE21934
BAE22437
BAE23298
CAA43692
CAI35128
CAI35129
CAI35132
CAI35133
CAI35134
CAQ52271
CAQ52272
CAQ52274
CAQ52275
CAQ52276
EDL15822
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