InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shank1

Summary

InnateDB Protein

IDBP-265618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shank1

Protein Name

SH3/ankyrin domain gene 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103571

InnateDB Gene

IDBG-178618 (Shank1)

Protein Structure

UniProt Annotation

Function

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Colocalizes with alpha-latrotoxin receptor 1. {ECO:0000250}.

Disease Associations

Tissue Specificity

In brain, highly expressed in cortex, hyppocampus and cerebellum. {ECO:0000269PubMed:21423165}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0017124	SH3 domain binding
GO:0030159	receptor signaling complex scaffold activity
GO:0030160	GKAP/Homer scaffold activity
GO:0031877	somatostatin receptor binding
GO:0032403	protein complex binding
GO:0035255	ionotropic glutamate receptor binding
GO:0042802	identical protein binding
GO:0071532	ankyrin repeat binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006461	protein complex assembly
GO:0007616	long-term memory
GO:0008306	associative learning
GO:0030534	adult behavior
GO:0032232	negative regulation of actin filament bundle assembly
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0042048	olfactory behavior
GO:0046959	habituation
GO:0050885	neuromuscular process controlling balance
GO:0050894	determination of affect
GO:0060013	righting reflex
GO:0060074	synapse maturation
GO:0060997	dendritic spine morphogenesis
GO:0060999	positive regulation of dendritic spine development
GO:0071625	vocalization behavior
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008328	ionotropic glutamate receptor complex
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

MGI:3613677

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR011510 Sterile alpha motif, type 2
IPR011511 Variant SH3 domain
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1

PFAM