Version 5.4
Mus musculus Protein: Tpm2
Summary
InnateDB Protein IDBP-265661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpm2
Protein Name tropomyosin 2, beta
Synonyms Tpm-2; Trop-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000103547
InnateDB Gene IDBG-141434 (Tpm2)
Protein Structure
UniProt Annotation
Function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000269PubMed:16094730}.
Subcellular Localization Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0006936 muscle contraction
GO:0043462 regulation of ATPase activity
Cellular Component
GO:0005862 muscle thin filament tropomyosin
Protein Structure and Domains
PDB ID MGI:98810
InterPro IPR000533 Tropomyosin
PFAM PF00261
PF12718
PRINTS PR00194
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58774
PhosphoSite PhosphoSite-P58774
TrEMBL Q6PJ18
UniProt Splice Variant
Entrez Gene 22004
UniGene Mm.646
RefSeq NP_001264805
MGI ID
MGI Symbol Tpm2
OMIM
CCDS CCDS71374
HPRD
IMGT
EMBL AL732506 BC024358 CH466565 M81086 X12650 X58381
GenPept AAA40484 AAH24358 CAA31181 CAA41271 EDL02469

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca