InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr1h2

Summary

InnateDB Protein

IDBP-265669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr1h2

Protein Name

nuclear receptor subfamily 1, group H, member 2

Synonyms

AI194859; LXR; LXRB; LXRbeta; NER1; OR-1; RIP15; Unr; Unr2; UR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103545

InnateDB Gene

IDBG-179265 (Nr1h2)

Protein Structure

UniProt Annotation

Function

Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. {ECO:0000269PubMed:18055760, ECO:0000269PubMed:19520913, ECO:0000269PubMed:20427281}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001133	sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010875	positive regulation of cholesterol efflux
GO:0010884	positive regulation of lipid storage
GO:0010887	negative regulation of cholesterol storage
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032369	negative regulation of lipid transport
GO:0042632	cholesterol homeostasis
GO:0043401	steroid hormone mediated signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045861	negative regulation of proteolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway
GO:0048550	negative regulation of pinocytosis
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0055088	lipid homeostasis
GO:0090108	positive regulation of high-density lipoprotein particle assembly
GO:0090187	positive regulation of pancreatic juice secretion
GO:0090340	positive regulation of secretion of lysosomal enzymes
GO:2000188	regulation of cholesterol homeostasis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1352463

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR003069 Ecdysteroid receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR023257 Liver X receptor

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546
PR01283
PR02034

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt