Version 5.4
Mus musculus Protein: Nme2
Summary
InnateDB Protein IDBP-265806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nme2
Protein Name non-metastatic cells 2, protein (NM23B) expressed in
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103476
InnateDB Gene IDBG-208539 (Nme2)
Protein Structure
UniProt Annotation
Function Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Exhibits histidine protein kinase activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Cell membrane. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the base region of the oxyntic and pyloric mucosae. {ECO:0000269PubMed:16476741}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004550 nucleoside diphosphate kinase activity
GO:0004673 protein histidine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0007229 integrin-mediated signaling pathway
GO:0018106 peptidyl-histidine phosphorylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0030027 lamellipodium
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID MGI:97356
InterPro IPR001564 Nucleoside diphosphate kinase
PFAM PF00334
PRINTS PR01243
PIRSF
SMART SM00562
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q01768
PhosphoSite PhosphoSite-Q01768
TrEMBL Q5NC82
UniProt Splice Variant
Entrez Gene 433968
UniGene Mm.320516
RefSeq NP_001070997
MGI ID
MGI Symbol Nme2
OMIM
CCDS CCDS25246
HPRD
IMGT
EMBL AK012447 AK150419 AK151262 AK169120 BC066995 BC086892 BC086893 CH466556 EF437324 X68193
GenPept AAH66995 AAH86892 AAH86893 ABS83502 BAB28246 BAE29543 BAE30250 BAE40900 CAA48275 EDL15908 EDL15909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca