InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il12a

Summary

InnateDB Protein

IDBP-265868.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il12a

Protein Name

interleukin 12a

Synonyms

Il-12a; IL-12p35; Ll12a; p35;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103446

InnateDB Gene

IDBG-150825 (Il12a)

Protein Structure

UniProt Annotation

Function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	3 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005143	interleukin-12 receptor binding
GO:0008083	growth factor activity
GO:0042163	interleukin-12 beta subunit binding

Biological Process

GO:0006955	immune response
GO:0032729	positive regulation of interferon-gamma production
GO:0042102	positive regulation of T cell proliferation
GO:0042832	defense response to protozoan
GO:0045087	innate immune response (InnateDB)
GO:0045582	positive regulation of T cell differentiation