InnateDB Protein
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IDBP-266038.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sphk2
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Protein Name
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sphingosine kinase 2
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Synonyms
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C76851;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103366
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InnateDB Gene
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IDBG-184179 (Sphk2)
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Protein Structure
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Function |
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides (By similarity). {ECO:0000250}.
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Subcellular Localization |
Lysosome membrane {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1861380
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InterPro |
IPR001206
Diacylglycerol kinase, catalytic domain
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PFAM |
PF00781
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PRINTS |
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PIRSF |
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SMART |
SM00046
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JIA7
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PhosphoSite |
PhosphoSite-Q9JIA7
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TrEMBL |
Q58E38
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UniProt Splice Variant |
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Entrez Gene |
56632
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UniGene |
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RefSeq |
NP_975009
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MGI ID |
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MGI Symbol |
Sphk2
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OMIM |
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CCDS |
CCDS21261
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HPRD |
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IMGT |
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EMBL |
AF245448
AF415214
AK004951
AK154321
BC006941
BC053737
BC092084
CH466603
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GenPept |
AAF74125
AAH06941
AAH53737
AAH92084
AAL07500
BAB23694
BAE32512
EDL22887
EDL22888
EDL22889
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