InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbkbp1

Summary

InnateDB Protein

IDBP-266291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbkbp1

Protein Name

TBK1 binding protein 1

Synonyms

3110043L15Rik; ProSAPiP2; SINTBAD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103239

InnateDB Gene

IDBG-210156 (Tbkbp1)

Protein Structure

UniProt Annotation

Function

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus. {ECO:0000269PubMed:17568778}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0045087	innate immune response

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1920424

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2A9T0

PhosphoSite

PhosphoSite-A2A9T0

TrEMBL

A2A9T1

UniProt Splice Variant

Entrez Gene

73174

UniGene

Mm.27882

RefSeq

XP_006534401

MGI ID

MGI Symbol

Tbkbp1

OMIM

CCDS

HPRD

IMGT

EMBL

AL627445 BC057590

GenPept

AAH57590 CAM26991 CAM26992