InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gas2

Summary

InnateDB Protein

IDBP-266344.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gas2

Protein Name

growth arrest specific 2

Synonyms

Gas-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103217

InnateDB Gene

IDBG-188499 (Gas2)

Protein Structure

UniProt Annotation

Function

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process. {ECO:0000269PubMed:10049561}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:8120096}. Membrane {ECO:0000269PubMed:8120096}; Peripheral membrane protein {ECO:0000269PubMed:8120096}. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane- associated. When hyperphosphorylated, accumulates at membrane ruffles.

Disease Associations

Tissue Specificity

Expressed in most tissues. Highest levels in liver, lung and kidney. In the embryo strongly expressed in regions that undergo extensive apoptosis, such as the intervertebral tissues, the cranofacial mesenchyme and the cartilage of the limbs.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.