Version 5.4
Mus musculus Gene: Gas2
Summary
InnateDB Gene IDBG-188499.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gas2
Gene Name growth arrest specific 2
Synonyms Gas-2
Species Mus musculus
Ensembl Gene ENSMUSG00000030498
Encoded Proteins
IDBP-188501
growth arrest specific 2
IDBP-266344
growth arrest specific 2
IDBP-266346
growth arrest specific 2
IDBP-536643
growth arrest specific 2
IDBP-539315
growth arrest specific 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148935:
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:51862015-51994975
Strand Forward strand
Band B4
Transcripts
ENSMUST00000051912 ENSMUSP00000053514
ENSMUST00000107591 ENSMUSP00000103217
ENSMUST00000107589 ENSMUSP00000103215
ENSMUST00000129604 ENSMUSP00000114743
ENSMUST00000132335
ENSMUST00000145049 ENSMUSP00000117367
ENSMUST00000155925
ENSMUST00000145723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0008360 regulation of cell shape
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148935
View Gene Order
ENSBTAG00000021654
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_210562
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13541
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
KEGG
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.207360
RefSeq NM_008087 XM_006540624
OMIM
CCDS CCDS21310
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca