Version 5.4
Mus musculus Protein: Sh2d2a
Summary
InnateDB Protein IDBP-266361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh2d2a
Protein Name SH2 domain protein 2A
Synonyms Lad; Ribp; Tsad;
Species Mus musculus
Ensembl Protein ENSMUSP00000103207
InnateDB Gene IDBG-158872 (Sh2d2a)
Protein Structure
UniProt Annotation
Function Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in p56-LCK- mediated T-cell signaling. Could be involved in the regulation of responses to T-cell activation stimuli, specifically proliferation and lymphokine production. Interactions with ITK and TXK may provide important biochemical links of these two important kinases with other components in the T-cell activation machinery. {ECO:0000269PubMed:10587356}.
Subcellular Localization Cytoplasm. Cell membrane. Note=Redistributed from cytoplasm to the plasma membrane in a T-cell activation- dependent manner.
Disease Associations
Tissue Specificity Expression limited to tissues of the immune system and, in particular, activated T-cells and natural killer cells. Expressed in the thymus, lymph node, and to a lesser extent, in the spleen and bone marrow. According to PubMed:10553045, also expressed in the lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0008283 cell proliferation
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1351596
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QXK9
PhosphoSite PhosphoSite-Q9QXK9
TrEMBL
UniProt Splice Variant
Entrez Gene 27371
UniGene Mm.86361
RefSeq NP_067284
MGI ID
MGI Symbol Sh2d2a
OMIM
CCDS CCDS38476
HPRD
IMGT
EMBL AF203343 U69490
GenPept AAB58422 AAF19396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca