Version 5.4
Mus musculus Gene: Sh2d2a
Summary
InnateDB Gene IDBG-158872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh2d2a
Gene Name SH2 domain protein 2A
Synonyms Lad; Ribp; Tsad
Species Mus musculus
Ensembl Gene ENSMUSG00000028071
Encoded Proteins
IDBP-158874
SH2 domain protein 2A
IDBP-266361
SH2 domain protein 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000027869:
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:87846755-87855722
Strand Forward strand
Band F1
Transcripts
ENSMUST00000029709 ENSMUSP00000029709
ENSMUST00000107581 ENSMUSP00000103207
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0008283 cell proliferation
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000027869
View Gene Order
ENSBTAG00000024470
Not yet available
Pathways
NETPATH
REACTOME
REACT_227951
Signaling by VEGF pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04370
VEGF signaling pathway pathway
INOH
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
KEGG
hsa04370
VEGF signaling pathway pathway
INOH
INOH website
VEGF signaling pathway pathway
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt Q9QXK9
TrEMBL Q5D0E4
UniProt Splice Variant
Entrez Gene 27371
UniGene Mm.86361
RefSeq NM_001025571 NM_021309
OMIM
CCDS CCDS17455 CCDS38476
HPRD
IMGT
MGI ID MGI:1351596
MGI Symbol Sh2d2a
EMBL AF203343 AK037489 BC034847 U69490
GenPept AAB58422 AAF19396 AAH34847 BAC29819
RNA Seq Atlas 27371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca