InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lpar1

Summary

InnateDB Protein

IDBP-266383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpar1

Protein Name

lysophosphatidic acid receptor 1

Synonyms

AI326300; Edg2; Gpcr26; Kdt2; lpA1; vzg-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103197

InnateDB Gene

IDBG-150490 (Lpar1)

Protein Structure

UniProt Annotation

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation (By similarity). {ECO:0000250}.

Subcellular Localization

Cell surface {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co- localizes with RALA in the endocytic vesicles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed within the embryonic cerebral cortex, where it is enriched in the ventricular zone. In the adult brain, also expressed in oligodendrocytes, as well as Schwann cells of the peripheral nervous system. Expressed in many other tissues, including testes, lung, heart, intestine, spleen, kidney, thymus, and stomach. No expression in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030165	PDZ domain binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010977	negative regulation of neuron projection development
GO:0032060	bleb assembly
GO:0035025	positive regulation of Rho protein signal transduction
GO:0042552	myelination
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410	positive regulation of MAPK cascade
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060999	positive regulation of dendritic spine development
GO:0071453	cellular response to oxygen levels
GO:0071673	positive regulation of smooth muscle cell chemotaxis

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle
GO:0043197	dendritic spine
GO:0043198	dendritic shaft

Protein Structure and Domains

PDB ID

MGI:108429

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002277 Lysophosphatidic acid receptor EDG-2
IPR004065 Lysophosphatidic acid receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01148
PR01527

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P61793