InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lpar1

Summary

InnateDB Gene

IDBG-150490.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpar1

Gene Name

lysophosphatidic acid receptor 1

Synonyms

AI326300; Edg2; Gpcr26; Kdt2; lpA1; vzg-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038668

Encoded Proteins

IDBP-150492

lysophosphatidic acid receptor 1

IDBP-266379

lysophosphatidic acid receptor 1

IDBP-266381

lysophosphatidic acid receptor 1

IDBP-266383

lysophosphatidic acid receptor 1

IDBP-266385

lysophosphatidic acid receptor 1

IDBP-542070

lysophosphatidic acid receptor 1

IDBP-541334

lysophosphatidic acid receptor 1

IDBP-537016

lysophosphatidic acid receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198121:
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:58435255-58553898

Strand

Reverse strand

Band

Transcripts

ENSMUST00000055018	ENSMUSP00000052581
ENSMUST00000107575	ENSMUSP00000103201
ENSMUST00000107574	ENSMUSP00000103200
ENSMUST00000107571	ENSMUSP00000103197
ENSMUST00000107570	ENSMUSP00000103196
ENSMUST00000155170	ENSMUSP00000121440
ENSMUST00000147354	ENSMUSP00000123694
ENSMUST00000145361	ENSMUSP00000116856

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030165	PDZ domain binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010942	positive regulation of cell death
GO:0010977	negative regulation of neuron projection development
GO:0022008	neurogenesis
GO:0032060	bleb assembly
GO:0035025	positive regulation of Rho protein signal transduction
GO:0042552	myelination
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410	positive regulation of MAPK cascade
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060999	positive regulation of dendritic spine development
GO:0071453	cellular response to oxygen levels
GO:0071673	positive regulation of smooth muscle cell chemotaxis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle
GO:0043197	dendritic spine
GO:0043198	dendritic shaft