InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdk12

Summary

InnateDB Protein

IDBP-266452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk12

Protein Name

cyclin-dependent kinase 12

Synonyms

1810022J16Rik; AI646528; Crk7; Crkrs; D11Ertd752e; Pksc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103162

InnateDB Gene

IDBG-210523 (Cdk12)

Protein Structure

UniProt Annotation

Function

Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269PubMed:22012619}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Colocalized with nuclear speckles throughout interphase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding

Biological Process

GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0008380	RNA splicing
GO:0043405	regulation of MAP kinase activity
GO:0046777	protein autophosphorylation
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain

Cellular Component

GO:0002944	cyclin K-CDK12 complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016607	nuclear speck
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex

Protein Structure and Domains

PDB ID

MGI:1098802

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt