Version 5.4
Mus musculus Gene: Cdk12
Summary
InnateDB Gene IDBG-210523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk12
Gene Name cyclin-dependent kinase 12
Synonyms 1810022J16Rik; AI646528; Crk7; Crkrs; D11Ertd752e; Pksc
Species Mus musculus
Ensembl Gene ENSMUSG00000003119
Encoded Proteins
IDBP-210525
cyclin-dependent kinase 12
IDBP-266450
cyclin-dependent kinase 12
IDBP-266452
cyclin-dependent kinase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167258:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:98203059-98278504
Strand Forward strand
Band D
Transcripts
ENSMUST00000003203 ENSMUSP00000003203
ENSMUST00000107539 ENSMUSP00000103163
ENSMUST00000107538 ENSMUSP00000103162
ENSMUST00000145113
ENSMUST00000147441
ENSMUST00000125152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0008380 RNA splicing
GO:0043405 regulation of MAP kinase activity
GO:0046777 protein autophosphorylation
GO:0070816 phosphorylation of RNA polymerase II C-terminal domain
Cellular Component
GO:0002944 cyclin K-CDK12 complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167258
View Gene Order
ENSBTAG00000013238
Not yet available
Cross-References
SwissProt Q14AX6
TrEMBL Q9CVL4
UniProt Splice Variant
Entrez Gene 69131
UniGene Mm.260516 Mm.398818 Mm.405451
RefSeq NM_001109626 XM_006534108 NM_001109628 NM_026952
OMIM
CCDS CCDS48901 CCDS25342 CCDS48902
HPRD
IMGT
MGI ID MGI:1098802
MGI Symbol Cdk12
EMBL AK007584 AK129237 AL591205 AY072295 BC116645
GenPept AAI16646 AAL69526 BAB25122 BAC98047 CAM21267 CAM21268 CAM21269 CAM21270
RNA Seq Atlas 69131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca