InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpm1

Summary

InnateDB Protein

IDBP-266486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpm1

Protein Name

transient receptor potential cation channel, subfamily M, member 1

Synonyms

4732499L03Rik; AI606771; Ltrpc1; melastatin; Mlsn1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103139

InnateDB Gene

IDBG-190849 (Trpm1)

Protein Structure

UniProt Annotation

Function

Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel. {ECO:0000269PubMed:19861548, ECO:0000269PubMed:19966281, ECO:0000269PubMed:9537257}.

Subcellular Localization

Cell membrane {ECO:0000255, ECO:0000305}; Multi-pass membrane protein {ECO:0000255, ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the retina where it localizes on dendritic tips of ON bipolar cells. Not detected in brain, lung, liver, heart, kidney, spleen or small intestine. Also expressed at high levels in poorly metastatic variants of B16 melanoma and at much reduced levels in highly metastatic variants of B16 melanoma. {ECO:0000269PubMed:19861548, ECO:0000269PubMed:19966281, ECO:0000269PubMed:9537257}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005261	cation channel activity
GO:0005262	calcium channel activity

Biological Process

GO:0007165	signal transduction
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007601	visual perception
GO:0046548	retinal rod cell development
GO:0060402	calcium ion transport into cytosol
GO:0070588	calcium ion transmembrane transport
GO:0071482	cellular response to light stimulus