InnateDB Protein
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IDBP-266642.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Adam15
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Protein Name
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a disintegrin and metallopeptidase domain 15 (metargidin)
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Synonyms
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MDC15; metargidin;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103070
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InnateDB Gene
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IDBG-163900 (Adam15)
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Protein Structure
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Function |
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration (By similarity). Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg. {ECO:0000250, ECO:0000269PubMed:11882657, ECO:0000269PubMed:12897135, ECO:0000269PubMed:15818704, ECO:0000269PubMed:18390692}.
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Subcellular Localization |
Endomembrane system {ECO:0000269PubMed:18390692}; Single-pass type I membrane protein {ECO:0000269PubMed:18390692}. Cell junction, adherens junction {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000269PubMed:18390692}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:18390692}. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed.
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Disease Associations |
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Tissue Specificity |
Expressed moderately in pericytes of retina. Expressed in testis and in spermatozoa from the caput, corpus, and cauda epididymis, as well as in non-capacitated and acrosome- reacted sperm (at protein level). Highly expressed in heart, brain, lung, and kidney. Expressed at lower levels in spleen, liver, testis and muscle. {ECO:0000269PubMed:18381816, ECO:0000269PubMed:18390692}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
30 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1333882
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InterPro |
IPR001590
Peptidase M12B, ADAM/reprolysin
IPR002870
Peptidase M12B, propeptide
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PFAM |
PF01421
PF01562
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O88839
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PhosphoSite |
PhosphoSite-O88839
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11490
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UniGene |
Mm.434209
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RefSeq |
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MGI ID |
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MGI Symbol |
Adam15
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB022089
AF006196
AK048901
AK149796
AK151804
AK152725
AK170101
BC009132
EF506571
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GenPept |
AAC61896
AAH09132
ABP73662
BAA88903
BAC33485
BAE29090
BAE30703
BAE31447
BAE41564
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