InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alad

Summary

InnateDB Protein

IDBP-266659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alad

Protein Name

aminolevulinate, delta-, dehydratase

Synonyms

ALADH; Lv;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103068

InnateDB Gene

IDBG-153421 (Alad)

Protein Structure

UniProt Annotation

Function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004655	porphobilinogen synthase activity
GO:0008270	zinc ion binding
GO:0032791	lead ion binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0033014	tetrapyrrole biosynthetic process
GO:0051260	protein homooligomerization
GO:0071353	cellular response to interleukin-4