Mus musculus Protein: Zbtb7b | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-266689.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Zbtb7b | ||||||||||||||||||||||
Protein Name | zinc finger and BTB domain containing 7B | ||||||||||||||||||||||
Synonyms | c-Krox; Thpok; Zfp67; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000103058 | ||||||||||||||||||||||
InnateDB Gene | IDBG-164322 (Zbtb7b) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes. {ECO:0000269PubMed:15729333, ECO:0000269PubMed:7937772}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. | ||||||||||||||||||||||
Disease Associations | Note=Defects in Zbtb7b are the cause of helper deficient disease (HD). HD mice are distinguished by the virtual absence of peripheral T-cells of the CD4(+)CD8(-) major histocompatibility complex (MHC) class II-restricted T-helper subset due to a specific block in thymic development. The developmental defect is selective for CD4(+)CD8(-) cells; the maturation of CD4(-)CD8(+) and gamma delta T-cells is normal indicating that lineage commitment is specifically perturbed without affecting positive selection. | ||||||||||||||||||||||
Tissue Specificity | Widely expressed, with a higher level in skin. Expressed in thymus. Restricted to CD4 cells (mature single positive CD4(+) and intermediate CD4(+)CD8(+) cells). {ECO:0000269PubMed:15729333, ECO:0000269PubMed:7937772}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:102755 | ||||||||||||||||||||||
InterPro |
IPR000210
BTB/POZ-like IPR007087 Zinc finger, C2H2 IPR011333 BTB/POZ fold IPR013069 BTB/POZ IPR015880 Zinc finger, C2H2-like |
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PFAM |
PF00096
PF00651 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00225
SM00355 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q64321 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q64321 | ||||||||||||||||||||||
TrEMBL | Q5BJ24 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 22724 | ||||||||||||||||||||||
UniGene | Mm.488956 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Zbtb7b | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS17504 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC171273 AK149976 BC046533 BC091651 L35307 Z36549 | ||||||||||||||||||||||
GenPept | AAA61956 AAH46533 AAH91651 BAE29206 CAA85307 | ||||||||||||||||||||||