InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP3B2

Summary

InnateDB Protein

IDBP-26677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP3B2

Protein Name

adaptor-related protein complex 3, beta 2 subunit

Synonyms

NAPTB;

Species

Homo sapiens

Ensembl Protein

ENSP00000261722

InnateDB Gene

IDBG-26673 (AP3B2)

Protein Structure

UniProt Annotation

Function

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Subcellular Localization

Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression). {ECO:0000269PubMed:1851215}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005488	binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0008089	anterograde axon cargo transport
GO:0016192	vesicle-mediated transport
GO:0048490	anterograde synaptic vesicle transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030117	membrane coat
GO:0030123	AP-3 adaptor complex
GO:0030137	COPI-coated vesicle
GO:0030665	clathrin-coated vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR016024 Armadillo-type fold
IPR026740 AP-3 complex subunit beta

PFAM

PF01602

PRINTS

PIRSF

PIRSF037096

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13367