Version 5.4
Homo sapiens Gene: AP3B2
Summary
InnateDB Gene IDBG-26673.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP3B2
Gene Name adaptor-related protein complex 3, beta 2 subunit
Synonyms NAPTB
Species Homo sapiens
Ensembl Gene ENSG00000103723
Encoded Proteins
IDBP-26677
adaptor-related protein complex 3, beta 2 subunit
IDBP-586491
adaptor-related protein complex 3, beta 2 subunit
IDBP-604021
adaptor-related protein complex 3, beta 2 subunit
IDBP-587466
adaptor-related protein complex 3, beta 2 subunit
IDBP-583987
adaptor-related protein complex 3, beta 2 subunit
IDBP-596573
adaptor-related protein complex 3, beta 2 subunit
IDBP-810053
adaptor-related protein complex 3, beta 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Adaptor protein-3 (AP3) is a heterotetrameric vesicle-coat protein complex. Some AP3 subunits are ubiquitously expressed, whereas others are expressed exclusively in neurons. The neuron-specific AP3 complex, which includes AP3B2, is thought to serve neuron-specific functions such as neurotransmitter release (Grabner et al., 2006 [PubMed 16788073]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:82659281-82709914
Strand Reverse strand
Band q25.2
Transcripts
ENST00000261722 ENSP00000261722
ENST00000543938
ENST00000537735
ENST00000535348 ENSP00000438721
ENST00000535359 ENSP00000440984
ENST00000545315
ENST00000538592 ENSP00000445804
ENST00000559888
ENST00000541693 ENSP00000441961
ENST00000535385
ENST00000542200 ENSP00000440719
ENST00000561455
ENST00000535513
ENST00000560529
ENST00000620652 ENSP00000479229
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005488 binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0008089 anterograde axon cargo transport
GO:0016192 vesicle-mediated transport
GO:0048490 anterograde synaptic vesicle transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0030117 membrane coat
GO:0030123 AP-3 adaptor complex
GO:0030137 COPI-coated vesicle
GO:0030665 clathrin-coated vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062444
View Gene Order
ENSBTAG00000008495
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.199593 Hs.597012
RefSeq NM_001278511 NM_001278512 NM_004644 XM_006720704 XM_006720705 XM_006720706
HUGO
OMIM
CCDS CCDS45331 CCDS61736 CCDS61737
HPRD 03699
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca