InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc45a

Summary

InnateDB Protein

IDBP-266816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc45a

Protein Name

unc-45 homolog A (C. elegans)

Synonyms

AW538196;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102991

InnateDB Gene

IDBG-195040 (Unc45a)

Protein Structure

UniProt Annotation

Function

May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen. {ECO:0000250, ECO:0000269PubMed:12356907, ECO:0000269PubMed:9209433, ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominant in the perinuclear region. Little protein in the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in spleen, bone marrow, lung and ovary, and at lower levels in testis, kidney, heart and brain (at protein level). Ubiquitous. Detected in uterus, large intestine, kidney, spleen, lung, brain, liver and ovary. {ECO:0000269PubMed:12356907, ECO:0000269PubMed:9209433}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0007517	muscle organ development
GO:0030154	cell differentiation
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2142246

InterPro

IPR013026 Tetratricopeptide repeat-containing domain
IPR016024 Armadillo-type fold
IPR019734 Tetratricopeptide repeat
IPR024660 UNC-45/Ring assembly protein 3

PFAM

PF13174
PF13176
PF13181
PF11701

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99KD5