Version 5.4
Mus musculus Gene: Unc45a
Summary
InnateDB Gene IDBG-195040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Unc45a
Gene Name unc-45 homolog A (C. elegans)
Synonyms AW538196
Species Mus musculus
Ensembl Gene ENSMUSG00000030533
Encoded Proteins
IDBP-195042
unc-45 homolog A (C. elegans)
IDBP-266816
unc-45 homolog A (C. elegans)
IDBP-538030
unc-45 homolog A (C. elegans)
IDBP-540708
unc-45 homolog A (C. elegans)
IDBP-540326
unc-45 homolog A (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140553:
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:80325292-80341005
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000032748 ENSMUSP00000032748
ENSMUST00000107368 ENSMUSP00000102991
ENSMUST00000154428 ENSMUSP00000119665
ENSMUST00000133728 ENSMUSP00000123399
ENSMUST00000141774
ENSMUST00000127997 ENSMUSP00000114428
ENSMUST00000145351
ENSMUST00000135503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0007517 muscle organ development
GO:0030154 cell differentiation
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140553
View Gene Order
ENSBTAG00000018639
Not yet available
Cross-References
SwissProt Q99KD5
TrEMBL
UniProt Splice Variant
Entrez Gene 101869
UniGene Mm.243024 Mm.469260
RefSeq NM_133952 XM_006540541
OMIM
CCDS CCDS21395
HPRD
IMGT
MGI ID MGI:2142246
MGI Symbol Unc45a
EMBL AK028912 AK047292 AK047476 AK166809 BC004717
GenPept AAH04717 BAC26192 BAC33017 BAC33070 BAE39037
RNA Seq Atlas 101869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca