InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASGEF1B

Summary

InnateDB Protein

IDBP-26686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGEF1B

Protein Name

RasGEF domain family, member 1B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264400

InnateDB Gene

IDBG-26684 (RASGEF1B)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro). {ECO:0000269PubMed:19645719, ECO:0000269PubMed:23894443}.

Subcellular Localization

Early endosome {ECO:0000250}. Late endosome {ECO:0000250}. Midbody {ECO:0000269PubMed:23894443}. Note=May shuttle between early and late endosomes (By similarity). Localizes to midbody at telophase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response (InnateDB)
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005769	early endosome
GO:0005770	late endosome
GO:0030496	midbody

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617

PRINTS

PIRSF

SMART

SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VAM2