Version 5.4
Homo sapiens Gene: RASGEF1B
Summary
InnateDB Gene IDBG-26684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASGEF1B
Gene Name RasGEF domain family, member 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138670
Encoded Proteins
IDBP-26686
RasGEF domain family, member 1B
IDBP-62093
RasGEF domain family, member 1B
IDBP-372614
RasGEF domain family, member 1B
IDBP-477318
RasGEF domain family, member 1B
IDBP-473858
RasGEF domain family, member 1B
IDBP-810477
RasGEF domain family, member 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20090772
RASGEF1B is a guanine-nucleotide exchange factor (GEF), whose expression is induced in macrophages on stimulation with toll-like receptor (TLR) agonists.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:81426393-82044244
Strand Reverse strand
Band q21.22
Transcripts
ENST00000264400 ENSP00000264400
ENST00000335927 ENSP00000338437
ENST00000436139 ENSP00000398763
ENST00000509081 ENSP00000425393
ENST00000504863 ENSP00000426929
ENST00000514889
ENST00000507538
ENST00000613784 ENSP00000484927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032320 positive regulation of Ras GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response (InnateDB)
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005769 early endosome
GO:0005770 late endosome
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029333
View Gene Order
ENSBTAG00000006561
Not yet available
Cross-References
SwissProt Q0VAM2
TrEMBL B4E121 D6RE71
UniProt Splice Variant
Entrez Gene 153020
UniGene Hs.480068 Hs.591696 Hs.614089
RefSeq NM_001300735 XM_005262776 NM_001300736 NM_152545 XM_005262777
HUGO HGNC:24881
OMIM 614532
CCDS CCDS75152 CCDS34022 CCDS75151
HPRD 17955
IMGT
EMBL AC006287 AC021863 AC093618 AC093747 AC093754 AC097477 AC112238 AC114746 AK056257 AK303625 BC121003 BC121004
GenPept AAI21004 AAI21005 AAY40982 AAY41054 BAB71130 BAG64633
RNA Seq Atlas 153020

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca