InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grm5

Summary

InnateDB Protein

IDBP-267051.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm5

Protein Name

glutamate receptor, metabotropic 5

Synonyms

6430542K11Rik; AI850523; Glu5R; Gprc1e; mGluR5; mGluR5b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102884

InnateDB Gene

IDBG-198166 (Grm5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001639	PLC activating G-protein coupled glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0008066	glutamate receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1351342

InterPro

IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000202 GPCR, family 3, metabotropic glutamate receptor 5
IPR000337 GPCR, family 3
IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR019588 Metabotropic glutamate receptor, Homer-binding domain
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003
PF10606

PRINTS

PR00593
PR01055
PR00248
PR01051

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite