InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grm5

Summary

InnateDB Gene

IDBG-198166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm5

Gene Name

glutamate receptor, metabotropic 5

Synonyms

6430542K11Rik; AI850523; Glu5R; Gprc1e; mGluR5; mGluR5b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049583

Encoded Proteins

IDBP-267051

glutamate receptor, metabotropic 5

IDBP-542223

glutamate receptor, metabotropic 5

IDBP-538968

glutamate receptor, metabotropic 5

IDBP-621860

glutamate receptor, metabotropic 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168959:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:87602544-88134907

Strand

Forward strand

Band

Transcripts

ENSMUST00000107263	ENSMUSP00000102884
ENSMUST00000125009	ENSMUSP00000118393
ENSMUST00000155358	ENSMUSP00000114927
ENSMUST00000138732
ENSMUST00000167164	ENSMUSP00000129181

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001639	PLC activating G-protein coupled glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0031687	A2A adenosine receptor binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0040013	negative regulation of locomotion
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0050890	cognition
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0070062	extracellular vesicular exosome
GO:0097449	astrocyte projection