InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sytl2

Summary

InnateDB Protein

IDBP-267157.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sytl2

Protein Name

synaptotagmin-like 2

Synonyms

AI266830; mKIAA1597; Slp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102829

InnateDB Gene

IDBG-198759 (Sytl2)

Protein Structure

UniProt Annotation

Function

Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. Required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology. Isoform 1 acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. Mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mucus granules with the apical plasma membrane. {ECO:0000269PubMed:15543135, ECO:0000269PubMed:16716193, ECO:0000269PubMed:18266782}.

Subcellular Localization

Isoform 1: Melanosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Bound to melanosomes. Isoform 1 is localized mainly on peripheral melanosomes but not on less mature melanosomes around the nucleus.Isoform 11: Cell membrane.

Disease Associations

Tissue Specificity

Highly expressed in brain, lung, kidney, testis and in embryos after day 7. Detected at lower levels in skeletal muscle. Expressed in pancreatic alpha cells. Isoform 6 is highly expressed in brain, but not detectable in the other tissues tested. Isoform 1 is expressed abundantly in the stomach and is predominantly localized at the apical region of gastric-surface mucus cells. Isoform 11 is expressed in cytotoxic T-lymphocytes (CTL). {ECO:0000269PubMed:11327731, ECO:0000269PubMed:16716193, ECO:0000269PubMed:17182843, ECO:0000269PubMed:18266782}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0017137	Rab GTPase binding
GO:0019902	phosphatase binding
GO:0042043	neurexin family protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0006904	vesicle docking involved in exocytosis
GO:0010923	negative regulation of phosphatase activity
GO:0070257	positive regulation of mucus secretion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0019897	extrinsic component of plasma membrane
GO:0033162	melanosome membrane
GO:0042470	melanosome
GO:0070382	exocytic vesicle