Version 5.4
Mus musculus Gene: Sytl2
Summary
InnateDB Gene IDBG-198759.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sytl2
Gene Name synaptotagmin-like 2
Synonyms AI266830; mKIAA1597; Slp2
Species Mus musculus
Ensembl Gene ENSMUSG00000030616
Encoded Proteins
IDBP-267157
synaptotagmin-like 2
IDBP-267159
synaptotagmin-like 2
IDBP-788314
synaptotagmin-like 2
IDBP-788317
synaptotagmin-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137501:
The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:90348699-90410439
Strand Forward strand
Band E1
Transcripts
ENSMUST00000098310
ENSMUST00000107211 ENSMUSP00000102829
ENSMUST00000107210 ENSMUSP00000102828
ENSMUST00000190837 ENSMUSP00000139450
ENSMUST00000190731 ENSMUSP00000139865
ENSMUST00000190365
ENSMUST00000189194
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0017137 Rab GTPase binding
GO:0019902 phosphatase binding
GO:0042043 neurexin family protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0010923 negative regulation of phosphatase activity
GO:0070257 positive regulation of mucus secretion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0033162 melanosome membrane
GO:0042470 melanosome
GO:0070382 exocytic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137501
View Gene Order
ENSBTAG00000000460
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.26751
RefSeq NM_001040085 NM_001289583 NM_001289584 NM_031394 XM_006508362 XM_006508363
OMIM
CCDS CCDS40017 CCDS40018
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca