InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Setdb1

Summary

InnateDB Protein

IDBP-267231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Setdb1

Protein Name

SET domain, bifurcated 1

Synonyms

AU022152; ESET; KMT1E; mKIAA0067;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102788

InnateDB Gene

IDBG-172468 (Setdb1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	13 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001833	inner cell mass cell proliferation
GO:0034968	histone lysine methylation
GO:0036124	histone H3-K9 trimethylation
GO:0060348	bone development

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1934229

InterPro

IPR001214 SET domain
IPR001739 Methyl-CpG DNA binding
IPR002999 Tudor domain
IPR003606 Pre-SET zinc-binding sub-group
IPR003616 Post-SET domain
IPR007728 Pre-SET domain
IPR016177 DNA-binding domain

PFAM

PF00856
PF01429
PF00567
PF05033

PRINTS

PIRSF

SMART

SM00317
SM00391
SM00333
SM00468
SM00508

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite