InnateDB Protein
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IDBP-267441.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pdzk1
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Protein Name
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PDZ domain containing 1
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Synonyms
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1700023D20Rik; 2610507N21Rik; 4921513F16Rik; AI267131; AI314638; AL022680; D3Ertd537e; mPDZK1; Pdzd1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000102685
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InnateDB Gene
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IDBG-176513 (Pdzk1)
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Protein Structure
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Function |
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride- anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. {ECO:0000250, ECO:0000269PubMed:11051556, ECO:0000269PubMed:12556478, ECO:0000269PubMed:14531806, ECO:0000269PubMed:15523054, ECO:0000269PubMed:16141316, ECO:0000269PubMed:20739281, ECO:0000269PubMed:21602281}.
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Subcellular Localization |
Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Note=Localized in the brush border membrane of renal proximal tubule cells. Associated with peripheral membranes. Localizes to the apical compartment of proximal cells and to sinusoidal liver membranes.
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Disease Associations |
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Tissue Specificity |
Expressed in kidney, liver, small intestine. brain, lung, and testis (at protein level). {ECO:0000269PubMed:11051556, ECO:0000269PubMed:12556478}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1928901
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InterPro |
IPR001478
PDZ domain
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PFAM |
PF00595
PF13180
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PRINTS |
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PIRSF |
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SMART |
SM00228
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JIL4
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PhosphoSite |
PhosphoSite-Q9JIL4
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TrEMBL |
D3Z114
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UniProt Splice Variant |
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Entrez Gene |
59020
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UniGene |
Mm.489677
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RefSeq |
NP_001139473
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MGI ID |
4F8K
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MGI Symbol |
Pdzk1
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OMIM |
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CCDS |
CCDS17649
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HPRD |
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IMGT |
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EMBL |
AC127297
AF220100
AF474247
AK006269
AK012070
AK014879
AK029752
AK029764
BC013512
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GenPept |
AAF73863
AAH13512
AAL84634
BAB24493
BAB28007
BAB29600
BAC26598
BAC26605
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