InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdzk1

Summary

InnateDB Gene

IDBG-176513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdzk1

Gene Name

PDZ domain containing 1

Synonyms

1700023D20Rik; 2610507N21Rik; 4921513F16Rik; AI267131; AI314638; AL022680; D3Ertd537e; mPDZK1; Pdzd1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038298

Encoded Proteins

IDBP-176515

PDZ domain containing 1

IDBP-267441

PDZ domain containing 1

IDBP-267443

PDZ domain containing 1

IDBP-542532

PDZ domain containing 1

IDBP-541091

PDZ domain containing 1

IDBP-542062

PDZ domain containing 1

IDBP-541347

PDZ domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174827:
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:96829284-96870926

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000058865	ENSMUSP00000058936
ENSMUST00000107070	ENSMUSP00000102685
ENSMUST00000107069	ENSMUSP00000102684
ENSMUST00000135031	ENSMUSP00000114157
ENSMUST00000138014	ENSMUSP00000115584
ENSMUST00000153256	ENSMUSP00000118846
ENSMUST00000128789	ENSMUSP00000123166

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005124	scavenger receptor binding
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0032403	protein complex binding

Biological Process

GO:0006810	transport
GO:0015879	carnitine transport
GO:0034767	positive regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0090002	establishment of protein localization to plasma membrane
GO:0090314	positive regulation of protein targeting to membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0031528	microvillus membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000174827

View Gene Order

ENSBTAG00000005810

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.489677

RefSeq

NM_001146001 NM_021517 XM_006501831 XM_006501832 XM_006501833 XM_006501834

OMIM

CCDS

CCDS17649

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas