InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdzk1

Summary

InnateDB Protein

IDBP-267443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdzk1

Protein Name

PDZ domain containing 1

Synonyms

1700023D20Rik; 2610507N21Rik; 4921513F16Rik; AI267131; AI314638; AL022680; D3Ertd537e; mPDZK1; Pdzd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102684

InnateDB Gene

IDBG-176513 (Pdzk1)

Protein Structure

UniProt Annotation

Function

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride- anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. {ECO:0000250, ECO:0000269PubMed:11051556, ECO:0000269PubMed:12556478, ECO:0000269PubMed:14531806, ECO:0000269PubMed:15523054, ECO:0000269PubMed:16141316, ECO:0000269PubMed:20739281, ECO:0000269PubMed:21602281}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Note=Localized in the brush border membrane of renal proximal tubule cells. Associated with peripheral membranes. Localizes to the apical compartment of proximal cells and to sinusoidal liver membranes.

Disease Associations

Tissue Specificity

Expressed in kidney, liver, small intestine. brain, lung, and testis (at protein level). {ECO:0000269PubMed:11051556, ECO:0000269PubMed:12556478}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005124	scavenger receptor binding
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0032403	protein complex binding

Biological Process

GO:0015879	carnitine transport
GO:0034767	positive regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0090002	establishment of protein localization to plasma membrane
GO:0090314	positive regulation of protein targeting to membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0031528	microvillus membrane
GO:0045121	membrane raft