InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eftud2

Summary

InnateDB Protein

IDBP-267452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eftud2

Protein Name

elongation factor Tu GTP binding domain containing 2

Synonyms

116kDa; Snrp116; U5-116kD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102675

InnateDB Gene

IDBG-212804 (Eftud2)

Protein Structure

UniProt Annotation

Function

Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006397	mRNA processing
GO:0007264	small GTPase mediated signal transduction
GO:0008380	RNA splicing

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005681	spliceosomal complex

Protein Structure and Domains

PDB ID

MGI:1336880

InterPro

IPR000640 Translation elongation factor EFG, V domain
IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR005517 Translation elongation factor EFG/EF2, domain IV
IPR009000 Translation protein, beta-barrel domain
IPR009022 Elongation factor G, III-V domain
IPR013684 Mitochondrial Rho-like
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00679
PF00009
PF03144
PF03764
PF14492
PF08477

PRINTS

PR00315

PIRSF

SMART

SM00838
SM00889

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt