Mus musculus Gene: Eftud2
Summary
InnateDB Gene IDBG-212804.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eftud2
Gene Name elongation factor Tu GTP binding domain containing 2
Synonyms 116kDa; Snrp116; U5-116kD;
Species Mus musculus
Ensembl Gene ENSMUSG00000020929
Encoded Proteins
elongation factor Tu GTP binding domain containing 2
elongation factor Tu GTP binding domain containing 2
elongation factor Tu GTP binding domain containing 2
elongation factor Tu GTP binding domain containing 2
elongation factor Tu GTP binding domain containing 2
elongation factor Tu GTP binding domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] EFTUD2 is a novel innate immune regulator that restricts hepatitis C virus infection through an RIG-I/MDA5-mediated, JAK-STAT-independent pathway.
[Homo sapiens] EFTUD2 is a novel innate immune antiviral regulator that restricts hepatitis C virus infection through a DDX58/IFIH1-mediated, JAK-STAT-independent pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108883:
This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:102838473-102880985
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000021306 ENSMUSP00000021306
ENSMUST00000107060 ENSMUSP00000102675
ENSMUST00000132543 ENSMUSP00000133732
ENSMUST00000143323
ENSMUST00000141273
ENSMUST00000131678
ENSMUST00000138483 ENSMUSP00000134725
ENSMUST00000123833
ENSMUST00000147368
ENSMUST00000148209
ENSMUST00000172611 ENSMUSP00000134316
ENSMUST00000173679 ENSMUSP00000134327
ENSMUST00000173974
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 92 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006397 mRNA processing
GO:0006414 translational elongation
GO:0007264 small GTPase mediated signal transduction
GO:0008380 RNA splicing
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA Splicing pathway
mRNA Splicing - Minor Pathway pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001109995 NM_011431 XM_006532665
OMIM
CCDS CCDS48947 CCDS48948
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas