InnateDB Protein
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IDBP-267476.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ucp3
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Protein Name
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uncoupling protein 3 (mitochondrial, proton carrier)
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Synonyms
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AI645527; Slc25a9; UCP-3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000102674
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InnateDB Gene
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IDBG-201426 (Ucp3)
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Protein Structure
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Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
0
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Protein-DNA |
1
[view]
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0017077
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oxidative phosphorylation uncoupler activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1099787
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InterPro |
IPR002030
Mitochondrial brown fat uncoupling protein
IPR018108
Mitochondrial substrate/solute carrier
IPR023395
Mitochondrial carrier domain
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PFAM |
PF00153
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PRINTS |
PR00784
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P56501
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B2RTM2
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UniProt Splice Variant |
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Entrez Gene |
22229
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UniGene |
Mm.6254
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RefSeq |
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MGI ID |
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MGI Symbol |
Ucp3
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OMIM |
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CCDS |
CCDS21497
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HPRD |
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IMGT |
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EMBL |
AB008216
AB010742
AB013132
AF019883
AF030164
AF032902
AF053352
BC139430
BC139431
CH466531
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GenPept |
AAB71543
AAB87084
AAC28328
AAD01892
AAI39431
AAI39432
BAA25697
BAA31989
BAA33502
EDL16446
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