Version 5.4
Mus musculus Protein: Arhgef17
Summary
InnateDB Protein IDBP-267533.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef17
Protein Name Rho guanine nucleotide exchange factor (GEF) 17
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000102647
InnateDB Gene IDBG-201713 (Arhgef17)
Protein Structure
UniProt Annotation
Function Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0030036 actin cytoskeleton organization
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:2673002
InterPro IPR000219 Dbl homology (DH) domain
IPR006077 Vinculin/alpha-catenin
IPR017986 WD40-repeat-containing domain
PFAM PF00621
PF01044
PRINTS
PIRSF
SMART SM00325
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80U35
PhosphoSite PhosphoSite-Q80U35
TrEMBL
UniProt Splice Variant
Entrez Gene 207212
UniGene Mm.29954
RefSeq NP_001074585
MGI ID
MGI Symbol Arhgef17
OMIM
CCDS CCDS40040
HPRD
IMGT
EMBL AC116586 AC150744 AK033211 AK122250
GenPept BAC28199 BAC65532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca