InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arap1

Summary

InnateDB Protein

IDBP-267555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arap1

Protein Name

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Synonyms

2410002L19Rik; Centd2; mKIAA0782;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102624

InnateDB Gene

IDBG-201910 (Arap1)

Protein Structure

UniProt Annotation

Function

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:Q96P48}. Golgi apparatus, Golgi stack membrane {ECO:0000250UniProtKB:Q96P48}; Peripheral membrane protein {ECO:0000250UniProtKB:Q96P48}. Cell membrane {ECO:0000250UniProtKB:Q96P48}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0031702	type 1 angiotensin receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0070412	R-SMAD binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007184	SMAD protein import into nucleus
GO:0008360	regulation of cell shape
GO:0032312	regulation of ARF GTPase activity
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051270	regulation of cellular component movement
GO:0051491	positive regulation of filopodium assembly
GO:0051497	negative regulation of stress fiber assembly
GO:0060395	SMAD protein signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0032580	Golgi cisterna membrane

Protein Structure and Domains

PDB ID

MGI:1916960

InterPro

IPR000159 Ras-association
IPR000198 Rho GTPase-activating protein domain
IPR001164 Arf GTPase activating protein
IPR001660 Sterile alpha motif domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00620
PF01412
PF00169
PF07647
PF00536

PRINTS

PR00405

PIRSF

SMART

SM00314
SM00324
SM00105
SM00454
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt