InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arap1

Summary

InnateDB Gene

IDBG-201910.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arap1

Gene Name

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Synonyms

2410002L19Rik; Centd2; mKIAA0782

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032812

Encoded Proteins

IDBP-201912

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-201916

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-201918

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-267555

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-538018

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-540315

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-536029

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-535208

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-531541

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-534910

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-537577

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-537983

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

IDBP-539999

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186635:
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:101348067-101412586

Strand

Forward strand

Band

Transcripts

ENSMUST00000084896	ENSMUSP00000081958
ENSMUST00000084895	ENSMUSP00000081957
ENSMUST00000098243	ENSMUSP00000095844
ENSMUST00000107010	ENSMUSP00000102624
ENSMUST00000137384	ENSMUSP00000118657
ENSMUST00000138628	ENSMUSP00000114197
ENSMUST00000133423	ENSMUSP00000121431
ENSMUST00000127873	ENSMUSP00000121257
ENSMUST00000152082
ENSMUST00000141083	ENSMUSP00000120168
ENSMUST00000148902	ENSMUSP00000123542
ENSMUST00000130016	ENSMUSP00000115850
ENSMUST00000134143	ENSMUSP00000115107
ENSMUST00000154239	ENSMUSP00000123298
ENSMUST00000155754
ENSMUST00000153340
ENSMUST00000156017
ENSMUST00000125284
ENSMUST00000124637

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0031702	type 1 angiotensin receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0070412	R-SMAD binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007184	SMAD protein import into nucleus
GO:0008360	regulation of cell shape
GO:0032312	regulation of ARF GTPase activity
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051270	regulation of cellular component movement
GO:0051491	positive regulation of filopodium assembly
GO:0051497	negative regulation of stress fiber assembly
GO:0060395	SMAD protein signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0032580	Golgi cisterna membrane