InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlk2

Summary

InnateDB Protein

IDBP-267718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlk2

Protein Name

tousled-like kinase 2 (Arabidopsis)

Synonyms

4933403M19Rik; PKU-alpha; PKUalpha; Tlk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102554

InnateDB Gene

IDBG-213211 (Tlk2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001672	regulation of chromatin assembly or disassembly
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007059	chromosome segregation
GO:0018105	peptidyl-serine phosphorylation
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556	intracellular signal transduction
GO:0071480	cellular response to gamma radiation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005882	intermediate filament
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1346023

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt