InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim21

Summary

InnateDB Protein

IDBP-267778.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Trim21

Protein Name

tripartite motif-containing 21

Synonyms

Ro52; Ssa1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102526

InnateDB Gene

IDBG-202909 (Trim21)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006513	protein monoubiquitination
GO:0031648	protein destabilization
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045787	positive regulation of cell cycle
GO:0046598	positive regulation of viral entry into host cell
GO:0051865	protein autoubiquitination
GO:0070206	protein trimerization
GO:0090086	negative regulation of protein deubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0019005	SCF ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:106657

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type
IPR020457 Zinc finger, B-box, chordata

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407
PR01406

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt