InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim21

Summary

InnateDB Gene

IDBG-202909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim21

Gene Name

tripartite motif-containing 21

Synonyms

Ro52; Ssa1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030966

Encoded Proteins

IDBP-202911

tripartite motif-containing 21

IDBP-267778

tripartite motif-containing 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22479513

Tyrosine phosphorylation of the E3 ubiquitin ligase Trim21 positively regulates interaction with Irf3 and hence Trim21 activity.

InnateDB Annotation from Orthologs

Summary

PMID 20627395

[Homo sapiens] TRIM21 (Ro52) conjugates phosphorylated IKBKB with monoubiquitin and the IKBKB-induced NFkappa B signalling is downregulated. TRIM21-mediated monoubiquitination is involved in the subcellular translocation of active IKBKB to autophagosomes.

PMID 20668674

[Homo sapiens] TRIM21 is a member of the TRIM family of single-protein E3 ligases and TRIM21-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation. As TRIM21 is also IFN-inducible, this system constitutes a negative-feedback loop that acts to protect the host from the prolonged activation of the immune response.

PMID 22479513

[Homo sapiens] Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.

PMID 23438823

[Homo sapiens] TRIM21 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132109:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:102557922-102565469

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033264	ENSMUSP00000033264
ENSMUST00000106913	ENSMUSP00000102526

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006513	protein monoubiquitination
GO:0031648	protein destabilization
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032897	negative regulation of viral transcription
GO:0045087	innate immune response (InnateDB)
GO:0045787	positive regulation of cell cycle
GO:0046598	positive regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865	protein autoubiquitination
GO:0070206	protein trimerization
GO:0090086	negative regulation of protein deubiquitination
GO:1902187	negative regulation of viral release from host cell