InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IMPA1

Summary

InnateDB Protein

IDBP-26798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IMPA1

Protein Name

inositol(myo)-1(or 4)-monophosphatase 1

Synonyms

IMP; IMPA;

Species

Homo sapiens

Ensembl Protein

ENSP00000256108

InnateDB Gene

IDBG-26796 (IMPA1)

Protein Structure

UniProt Annotation

Function

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. {ECO:0000269PubMed:17068342}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008934	inositol monophosphate 1-phosphatase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0052832	inositol monophosphate 3-phosphatase activity
GO:0052833	inositol monophosphate 4-phosphatase activity

Biological Process

GO:0006021	inositol biosynthetic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006796	phosphate-containing compound metabolic process
GO:0007165	signal transduction
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0046855	inositol phosphate dephosphorylation