Version 5.4
Mus musculus Protein: Rhoc
Summary
InnateDB Protein IDBP-268050.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhoc
Protein Name ras homolog gene family, member C
Synonyms AI324259; Arh9; Arhc;
Species Mus musculus
Ensembl Protein ENSMUSP00000102399
InnateDB Gene IDBG-183068 (Rhoc)
Protein Structure
UniProt Annotation
Function Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269PubMed:20974804}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cleavage furrow {ECO:0000250}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0000910 cytokinesis
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043297 apical junction assembly
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032154 cleavage furrow
Protein Structure and Domains
PDB ID MGI:106028
InterPro IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00009
PF00071
PF00025
PF08477
PRINTS PR00315
PR00449
PR00328
PIRSF
SMART SM00174
SM00175
SM00173
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62159
PhosphoSite PhosphoSite-Q62159
TrEMBL
UniProt Splice Variant
Entrez Gene 11853
UniGene
RefSeq
MGI ID
MGI Symbol Rhoc
OMIM
CCDS CCDS17704
HPRD
IMGT
EMBL AK011599 AK152802 AK160650 BC004627 X80638
GenPept AAH04627 BAB27724 BAE31507 BAE35941 CAA56682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca