InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rhoc

Summary

InnateDB Gene

IDBG-183068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rhoc

Gene Name

ras homolog gene family, member C

Synonyms

AI324259; Arh9; Arhc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002233

Encoded Proteins

IDBP-183070

ras homolog gene family, member C

IDBP-268050

ras homolog gene family, member C

IDBP-716379

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155366:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:104789011-104794459

Strand

Forward strand

Band

F2.2

Transcripts

ENSMUST00000002303	ENSMUSP00000002303
ENSMUST00000106787	ENSMUSP00000102399
ENSMUST00000132721
ENSMUST00000176347	ENSMUSP00000135659

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000910	cytokinesis
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043297	apical junction assembly

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032154	cleavage furrow
GO:0070062	extracellular vesicular exosome