InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrp8

Summary

InnateDB Protein

IDBP-268155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrp8

Protein Name

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Synonyms

4932703M08Rik; AA921429; AI848122; ApoER2; Lr8b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102343

InnateDB Gene

IDBG-171850 (Lrp8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008035	high-density lipoprotein particle binding
GO:0019894	kinesin binding
GO:0030229	very-low-density lipoprotein particle receptor activity

Biological Process

GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0021766	hippocampus development
GO:0021819	layer formation in cerebral cortex
GO:0021987	cerebral cortex development
GO:0042493	response to drug
GO:0045860	positive regulation of protein kinase activity
GO:0071363	cellular response to growth factor stimulus
GO:0071397	cellular response to cholesterol

Cellular Component

GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:1340044

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF00058
PF00008
PF07645
PF00057

PRINTS

PR00261

PIRSF

SMART

SM00135
SM00181
SM00179
SM00192

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt