InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lrp8

Summary

InnateDB Gene

IDBG-171850.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrp8

Gene Name

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Synonyms

4932703M08Rik; AA921429; AI848122; ApoER2; Lr8b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028613

Encoded Proteins

IDBP-171852

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-268153

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-268155

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-268157

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-535881

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-532261

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157193:
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:107802261-107876840

Strand

Forward strand

Band

Transcripts

ENSMUST00000030356	ENSMUSP00000030356
ENSMUST00000106733	ENSMUSP00000102344
ENSMUST00000106732	ENSMUSP00000102343
ENSMUST00000106731	ENSMUSP00000102342
ENSMUST00000143601	ENSMUSP00000115854
ENSMUST00000126573	ENSMUSP00000118020
ENSMUST00000147319
ENSMUST00000146552
ENSMUST00000123140
ENSMUST00000145832
ENSMUST00000135591
ENSMUST00000135022

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005041	low-density lipoprotein receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008035	high-density lipoprotein particle binding
GO:0019894	kinesin binding
GO:0030229	very-low-density lipoprotein particle receptor activity
GO:0034185	apolipoprotein binding
GO:0038025	reelin receptor activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0021517	ventral spinal cord development
GO:0021541	ammon gyrus development
GO:0021766	hippocampus development
GO:0021819	layer formation in cerebral cortex
GO:0021987	cerebral cortex development
GO:0032793	positive regulation of CREB transcription factor activity
GO:0038026	reelin-mediated signaling pathway
GO:0042493	response to drug
GO:0045860	positive regulation of protein kinase activity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804	regulation of synaptic transmission
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0071363	cellular response to growth factor stimulus
GO:0071397	cellular response to cholesterol
GO:1900006	positive regulation of dendrite development

Cellular Component

GO:0005615	extracellular space
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043235	receptor complex