InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abca8a

Summary

InnateDB Protein

IDBP-268298.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abca8a

Protein Name

ATP-binding cassette, sub-family A (ABC1), member 8a

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102275

InnateDB Gene

IDBG-213891 (Abca8a)

Protein Structure

UniProt Annotation

Function

ATP-dependent lipophilic drug transporter. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in lung, heart, liver, skeletal muscle and testis. {ECO:0000269PubMed:12532264, ECO:0000269PubMed:16445568}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0008150	biological_process

Cellular Component

GO:0005575	cellular_component
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2386846

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR004881 Ribosome biogenesis GTPase RsgA, putative
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF03193

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K442